Which hormone from the pancreas lowers blood sugar via negative feedback?

• A. Glucagon
• B. Insulin
• C. Epinephrine
• D. Calcitonin

Answer: (B)

The question targets how blood glucose is kept steady by pancreatic hormones working through negative feedback. Insulin, produced by the beta cells, is released when blood glucose is high. It promotes glucose uptake into liver, muscle, and adipose tissue and stimulates the liver to store glucose as glycogen and to limit glucose production. As blood glucose returns toward normal, insulin secretion drops, so the signal is countered and the level remains balanced. The other hormones don’t lower blood sugar in this way: glucagon raises blood sugar by promoting glucose production in the liver, epinephrine increases glucose during stress, and calcitonin mainly handles calcium balance. Therefore, insulin is the best fit.